14) Concerning the calculation of dosing regimens for F= 0.90 Bound in plasma = 56 Volume of distribution= 35 liters/70kg Drug X may require the following data: Clearance 2.9 liters/hr/70kg (constant) Half-life 8.1hr
Effective concentration= 20 micrograms/milliliter Answer Each Following (a,b,c,d) Toxic concentration= 30 micrograms/milliliter
a- A 57-year old adult male (70 kg) who recently suffered a myocardial infarction presents in the ER with acute ventricular arrhythmias.
The physician orders a loading dose of Drug X to be followed by continuous intravenous dosing to maintain plasma levels of Drug X at an effective concentration.
The correct loading dose of this drug to administer would be?
b- The intravenous dosing rate necessary to maintain plasma drug levels at 20 micrograms/milliliter is?
c- If a loading dose were not administered, the time required to reach the target plasma level of 20
micrograms/milliliter would be approximately?
d- After the patient is discharged, the ORAL MAINTENANCE dose given every 6 hours (dosing interval = 6 hours) necessary to maintain plasma drug levels af 20 micrograms/milliliter is?
